Northwestern and Duke clash this weekend in a Big Ten vs ACC matchup. Our A.I. prediction model has crunched the numbers to make its Northwestern vs Duke prediction.
How Our NCAAF Prediction Model Works
Our model determines expected points scored based on:
- Actual points per game
- Offensive and defensive ratings
- Opponent ratings
- Home field advantage
We combine these factors into an expected score for each team.
Key Factors in the Northwestern vs Duke Prediction
- Duke has the edge in passing and rushing offense
- Northwestern is slightly better in rushing defense
- Duke appears to have the overall advantage
Final Northwestern vs Duke Prediction
Our model predicts Duke beats Northwestern 30-19 at home.
The Blue Devils have the offensive firepower to get the win, but not to cover.
Best Bet: Northwestern +18.5

The Bottom Line
Our A.I. predicts Duke will not cover -18.5 against Northwestern.